In a condition called complete heterochromia, the whole iris of one eye is a different color from the iris of the other eye. Partial heterochromia, meanwhile, is said to occur when part of one iris is a different color from the rest of the iris in one eye. It's a result of the relative excess or lack of melanin. It may be inherited, or caused by genetic mosaicism, disease or injury.
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Famous Angora cat (Ankara cat) has eyes with two different colours.
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