On the face of things, a hot waffle iron wouldn't seem to have all that much in common with a block of ice. But the two objects share the same capacity to inflict pain. Extreme heat and extreme cold are both able to deliver a nasty blow to human skin, and it turns out that the brain monitors these thermal extremes in similar ways.
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Sunburn sensitizes our heat-detecting channel, lowering the threshold at which we feel pain. The best understood of them is called TRPV1, and it responds to extreme heat. ... Together these three proteins – TRPV1, TRPM8, and TRPA1 – enable the skin to detect a range of temperatures and the body to respond accordingly.
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This article highlights an intriguing aspect of human perception—our brain registers extreme temperatures, whether hot or cold, as painful experiences. This is because specialized nerve endings in our skin, called nociceptors, detect harmful stimuli and send distress signals to the brain. Interestingly, both heat and cold trigger similar pain pathways, reinforcing how our nervous system prioritizes survival by alerting us to potential danger. A hot waffle iron and a block of ice may seem unrelated, but physiologically, they provoke a common response: protect yourself!
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